Phospholipase C Activator,
2,4,6-Trimethyl-N-(M-3-Trifluoromethyl)Phenyl)Benzenesulfonamide
CAS: 200933-14-8
Molecular Formula: C16H16F3NO2S
Phospholipase C Activator, - Names and Identifiers
Phospholipase C Activator, - Physico-chemical Properties
| Molecular Formula | C16H16F3NO2S |
| Molar Mass | 343.36 |
| Density | 1.316±0.06 g/cm3(Predicted) |
| Melting Point | 114-114.8°C(lit.) |
| Boling Point | 420.0±55.0 °C(Predicted) |
| Solubility | DMSO: 92mg/mL |
| Appearance | solid |
| Color | white |
| pKa | 7.82±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| In vitro study | m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells. m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis. Cell Viability Assay Cell Line: U937 and THP-1 cells Concentration: 50 μM Incubation Time: 24 hours Result: Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. Cell Viability Assay Cell Line: U937 cells Concentration: 50 μM Incubation Time: 24 hours Result: The apoptotic rate of m-3M3FBS-treated cells was 53.9%. |
Phospholipase C Activator, - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
Phospholipase C Activator, - Reference Information
| biological activity | m-3M3FBS is an effective phospholipase C (PLC) activator. m-3M3FBS stimulates human neutrophils to produce superoxide, up-regulates intracellular calcium ion concentration, and stimulates various cells to produce inositol phosphate. m-3M3FBS induces apoptosis in monocytic leukemia cells (apoptosis). |
| in vitro study | m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells. m-3 M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. m-3 M3FBS (50 μM; 24 hours) induces U937 cell apoptosis. Cell Viability Assay Cell Line: U937 and THP-1 cells Concentration: 50 μM Incubation Time: 24 hours Result: Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. Cell Viability Assay Cell Line: U937 cells Concentration: 50 μM Incubation Time: 24 hours Result: the apoptotic rate of m-3M3FBS-treated cells was 53.9%. |
| Cell Line: | U937 and THP-1 cells U937 cells |
| Concentration: | 50 μM 50 μM |
| Incubation Time: | 24 hours 24 hours |
| Result: | Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. The apoptotic rate of m-3M3FBS-treated cells was 53.9%. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: 2,4,6-Trimethyl-N-(M-3-Trifluoromethyl)Phenyl)Benzenesulfonamide Visit Supplier Webpage Request for quotationCAS: 200933-14-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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